Project information
Development of new diagnostic teniques for oncology
- Project Identification
- IBS5004010
- Project Period
- 1/2000 - 1/2004
- Investor / Pogramme / Project type
-
Academy of Sciences of the Czech Republic
- Programme of Targeted Research and Development Support
- MU Faculty or unit
- Faculty of Informatics
- Cooperating Organization
-
Institute of Biophysics
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
The project is directed to the improvement of diagnostic techniques in oncology both in primary diseases and in related infections. The development of high-resolution cytometric techniques and methods of the detection of the telomerase activity will be the goals of the project. Topographic characteristics of appropriate genetic loci in selected tumour tissues will be mesured and correlated to tumour characteristcs. The development of techniques and methods for clinical applications will be followed by industrial development of a confocal cytometr. In addition, methods of detection of the telomerase activity and expresion will be optimised both for the diagnostic purposes, and for testing the sensitivity of cultured tumor cells to cytostatics and potential cytostatic agents. The improvement of diagnostic techniques of fungal infections typical of oncological patients will be the additional goal of the project. DNA probes will be prepared for clinica diagnostics.
Publications
Total number of publications: 54
2001
-
In Situ Analysis of Telomeres in Haematological Malignancies
European Journal of Human Genetics, year: 2001
-
Spherical Object Reconstruction Using Star-Shaped Simplex Meshes
Energy Minimization Methods in Computer Vision and Pattern Recognition, year: 2001
2000
-
An efficient algorithm for measurement and correction of chromatic aberrations in fluorescence microscopy
Journal of Microscopy, year: 2000, volume: 200, edition: 3
-
Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differentiation and after irradiation
Chromosome Research, year: 2000, volume: 8, edition: 6