Project information
Development of new diagnostic teniques for oncology
- Project Identification
- IBS5004010
- Project Period
- 1/2000 - 1/2004
- Investor / Pogramme / Project type
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Academy of Sciences of the Czech Republic
- Programme of Targeted Research and Development Support
- MU Faculty or unit
- Faculty of Informatics
- Cooperating Organization
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Institute of Biophysics
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
The project is directed to the improvement of diagnostic techniques in oncology both in primary diseases and in related infections. The development of high-resolution cytometric techniques and methods of the detection of the telomerase activity will be the goals of the project. Topographic characteristics of appropriate genetic loci in selected tumour tissues will be mesured and correlated to tumour characteristcs. The development of techniques and methods for clinical applications will be followed by industrial development of a confocal cytometr. In addition, methods of detection of the telomerase activity and expresion will be optimised both for the diagnostic purposes, and for testing the sensitivity of cultured tumor cells to cytostatics and potential cytostatic agents. The improvement of diagnostic techniques of fungal infections typical of oncological patients will be the additional goal of the project. DNA probes will be prepared for clinica diagnostics.
Publications
Total number of publications: 54
2003
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Topography of telomeres and structure of chromosome territories in human lymphocytes
Biophysics of the Genome, year: 2003
2002
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3D Structure of the human genome: Order in randomness
Chromosoma, year: 2002, volume: 111, edition: 5
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Algorithms and data representation in the FISH 3.0 image processing system
Biophysics of the genome and its interactions, year: 2002
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Cell Nuclei Segmentation Using Star-Shaped Simplex Meshes
Biophysics of the Genome and Its Interactions, year: 2002
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Cytogenetics of Retinoblastoma
Biophysics of the genome and its interactions, year: 2002
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Effectivity of Spherical Object Reconstruction Using Star-Shaped Simplex Meshes
1st International Symposium on 3D Data Processing Visualization and Transmission, year: 2002
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FISH 3.0 client-server system for 3D optical microscope data storage and analysis
Biophysics of the genome and its interactions, year: 2002
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High-resolution cytometry network project: Towards remote and distributed acquisition, processing and visualisation of 3D image data in human genome research
3D data processing, visualization and transmission, year: 2002
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Chromatin modifications determined in retinoblastoma
Year: 2002, type: Conference abstract
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Nuclear structure and gene activity in human differentiated cells
Journal of Structural Biology, year: 2002, volume: 139, edition: 2