Project information
Development of new diagnostic teniques for oncology
- Project Identification
- IBS5004010
- Project Period
- 1/2000 - 1/2004
- Investor / Pogramme / Project type
-
Academy of Sciences of the Czech Republic
- Programme of Targeted Research and Development Support
- MU Faculty or unit
- Faculty of Informatics
- Cooperating Organization
-
Institute of Biophysics
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
The project is directed to the improvement of diagnostic techniques in oncology both in primary diseases and in related infections. The development of high-resolution cytometric techniques and methods of the detection of the telomerase activity will be the goals of the project. Topographic characteristics of appropriate genetic loci in selected tumour tissues will be mesured and correlated to tumour characteristcs. The development of techniques and methods for clinical applications will be followed by industrial development of a confocal cytometr. In addition, methods of detection of the telomerase activity and expresion will be optimised both for the diagnostic purposes, and for testing the sensitivity of cultured tumor cells to cytostatics and potential cytostatic agents. The improvement of diagnostic techniques of fungal infections typical of oncological patients will be the additional goal of the project. DNA probes will be prepared for clinica diagnostics.
Publications
Total number of publications: 54
2004
-
Telomerase activity in multiple myeloma patients
Year: 2004, type: R&D Presentation
-
Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo
Year: 2004, type: Conference abstract
-
Towards a Fully Automated Tissue Cell Segmentation Method
Visualization, Imaging, and Image Processing, year: 2004
2003
-
3D Object reconstructions in image cytometry
Biophysics of the Genome, year: 2003
-
A network solution for high-resolution image cytometry
Biophysics of the Genome, year: 2003
-
Analýza telomer nádorových buněk technikami in situ
Časopis Lékařů českých, year: 2003, volume: 142, edition: 8
-
Architecture of chromosomal territories in apoptotic cells
Biophysics of the Genome, year: 2003
-
Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI-1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells
Human Genetics, year: 2003, volume: 112, edition: 2
-
Cytogenetics and cytology of retinoblastomas
J Cancer Res. Clin.Oncol., year: 2003, volume: 129, edition: 2
-
Dual-color real-time telomeric repeat amplification protocol
BioTechniques, year: 2003, volume: 35, edition: 5