Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 180
2021
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Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers
ACS Catalysis, rok: 2021, ročník: 11, vydání: 21, DOI
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COVALENTLY CROSS-LINKED HYALURONIC ACID/BSA/GELATINE HYDROGELS AS BETTER SURFACE FOR CELL CULTURE
CONFERENCE PROCEEDINGS - NANOCON 2020, rok: 2021
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Cucurbiturils Monofunctionalized on the Methylene Bridge and Their Host-Guest Properties
European Journal of Organic Chemistry, rok: 2021, ročník: 2021, vydání: 33, DOI
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Data handling workshop
Rok: 2021, druh: Uspořádání workshopu
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Development of 48-condition buffer screen for protein stability assessment
European Biophysics Journal With Biophysics Letters, rok: 2021, ročník: 50, vydání: 3-4, DOI
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Development of 48-condition buffer screen for protein stability assessment
Rok: 2021, druh: Konferenční abstrakty
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Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier
Carbohydrate Polymers, rok: 2021, ročník: 272, vydání: November 2021, DOI
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Establishing of ARBRE – Association of Resources for Biophysical Research in Europe
Rok: 2021, druh: Konferenční abstrakty
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Functional analysis of new variant GP1BA gene in inherited macrotrombocytopenia.
Rok: 2021, druh: Konferenční abstrakty
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Hydrogen-bond directionality and symmetry in [C(O)NH](N)(2)P(O)-based structures: a comparison between X-ray crystallography data and neutron-normalized values, and evaluation of reliability
Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, rok: 2021, ročník: 77, vydání: 3, DOI