Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals
Autoři | |
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Rok publikování | 2010 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Inorganic Chemistry Communications |
Fakulta / Pracoviště MU | |
Citace | |
www | http://linkinghub.elsevier.com/retrieve/pii/S1387700310003084 |
Obor | Anorganická chemie |
Klíčová slova | Decomposition of copper complexes; Kinetics; Electrolyte media; Copper-64 radiopharmaceuticals |
Popis | The kinetics of decomposition of a macrocyclic Cu2+ complex is strongly dependent on the anions in solution. In particular, chloride anions accelerate significantly the decomposition process, even out of the stopped-flow time scale. Given the different chloride concentrations in biological media, the possibility of changes in the decomposition kinetics must be considered when designing 64Cu radiopharmaceuticals. |
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