Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals

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Authors	BASALLOTE Manuel G. CASTILLO Carmen E. MÁNEZ M. Angeles LUBAL Přemysl MARTÍNEZ Manuel RODRÍGUEZ Carlos VANĚK Jakub
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Inorganic Chemistry Communications
MU Faculty or unit	Faculty of Science
Citation
Web	http://linkinghub.elsevier.com/retrieve/pii/S1387700310003084
Field	Inorganic chemistry
Keywords	Decomposition of copper complexes; Kinetics; Electrolyte media; Copper-64 radiopharmaceuticals
Description	The kinetics of decomposition of a macrocyclic Cu2+ complex is strongly dependent on the anions in solution. In particular, chloride anions accelerate significantly the decomposition process, even out of the stopped-flow time scale. Given the different chloride concentrations in biological media, the possibility of changes in the decomposition kinetics must be considered when designing 64Cu radiopharmaceuticals.
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