Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells
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Rok publikování | 2003 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Anticancer Research |
Fakulta / Pracoviště MU | |
Citace | FAJKUS, Jiří, Marek BORSKÝ, Zuzana KUNICKÁ, Martina KOVAŘÍKOVÁ, Dana DVOŘÁKOVÁ, Jiřina HOFMANOVÁ a Alois KOZUBÍK. Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells. Anticancer Research. Athens: INT INST ANTICANCER RESEARCH, 2003, Neuveden, č. 23, s. 1605-1612. ISSN 0250-7005. |
Obor | Genetika a molekulární biologie |
Klíčová slova | telomerase regulation; human colon cells; butyrate; alternative splicing; flow cytometry |
Popis | Downregulation of telomerase activity and expression occurs in response to butyrate-induced differentiation in normal and carcinoma colon cells. Differential splicing of hTERT mRNA may be involved in faster loss of telomerase activity in normal cells with respect to malignant cells. |
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