Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells

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Authors

FAJKUS Jiří BORSKÝ Marek KUNICKÁ Zuzana KOVAŘÍKOVÁ Martina DVOŘÁKOVÁ Dana HOFMANOVÁ Jiřina KOZUBÍK Alois

Year of publication 2003
Type Article in Periodical
Magazine / Source Anticancer Research
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords telomerase regulation; human colon cells; butyrate; alternative splicing; flow cytometry
Description Downregulation of telomerase activity and expression occurs in response to butyrate-induced differentiation in normal and carcinoma colon cells. Differential splicing of hTERT mRNA may be involved in faster loss of telomerase activity in normal cells with respect to malignant cells.
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