GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia
| Autoři | |
|---|---|
| Rok publikování | 2013 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | BIOLOGY DIRECT |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.biologydirect.com/content/8/1/5 |
| Doi | http://dx.doi.org/10.1186/1745-6150-8-5 |
| Obor | Genetika a molekulární biologie |
| Klíčová slova | Schizophrenia; Human endogenous retrovirus; HERV-W; long terminal repeat; LTR; GABA; GABBR1; GABA receptor; Enhancer; Silencer |
| Přiložené soubory | |
| Popis | Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1. |
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