GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia

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Authors	HEGYI Hedvig
Year of publication	2013
Type	Article in Periodical
Magazine / Source	BIOLOGY DIRECT
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.biologydirect.com/content/8/1/5
Doi	http://dx.doi.org/10.1186/1745-6150-8-5
Field	Genetics and molecular biology
Keywords	Schizophrenia; Human endogenous retrovirus; HERV-W; long terminal repeat; LTR; GABA; GABBR1; GABA receptor; Enhancer; Silencer
Attached files	Hegyi_1745-6150-8-5.pdf
Description	Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.
Related projects:	CEITEC - Central European Institute of Technology