Bone marrow plasma cell separation - validation of separation algorithm
Autoři | |
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Rok publikování | 2012 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Clinical Chemistry and Laboratory medicine |
Fakulta / Pracoviště MU | |
Citace | |
Doi | http://dx.doi.org/10.1515/cclm-2012-8837 |
Obor | Onkologie a hematologie |
Klíčová slova | FACS; MACS; monoclonal gammopathy; multiple myeloma; plasma cell |
Přiložené soubory | |
Popis | Monoclonal gammopathy is characterized by the presence of monoclonal immunoglobulin which is produced by a specifi c clone of terminally differentiated long-living plasma cells (PC) in the bone marrow. More detailed understanding of this clone at the genomic and proteomic level as well as its comparison with the population of normal PC is possible only after the clone is separated from other BM cells. |
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