Project information
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
- Project Identification
- NU22-02-00348
- Project Period
- 5/2022 - 12/2025
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Cooperating Organization
-
University Hospital Brno-Bohunice
- Responsible person doc. MUDr. Tomáš Novotný, Ph.D.
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
Publications
Total number of publications: 26
2024
-
Analysis of calcium transients in cardiomyocytes derived from hiPSCs: the variant p. Y4734C in RYR2 vs. unrelated healthy controls
Year: 2024, type: Conference abstract
-
Effect of isoprenaline and arrhythmogenic conditions on the spontaneous electrical activity of hiPSC-CM with Y4734C-RYR2 variant
Year: 2024, type: Conference abstract
-
Functional consequences of changes in the distribution of Ca2+ extrusion pathways between t-tubular and surface membranes in a model of human ventricular cardiomyocyte
Journal of Molecular and Cellular Cardiology, year: 2024, volume: 193, edition: August 2024, DOI
-
Idiopathic ventricular fibrillation: a role of variants in the hERG gene
Year: 2024, type: Conference abstract
-
The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting
Scientific Reports, year: 2024
-
Variants in the hERG channel associated with idiopathic ventricular fibrillation: clinical, genetic, and functional analysis
Year: 2024, type:
-
Vliv varianty S1021Qfs*98 v genu hERG na aktivaci a deaktivaci proteinu Kv11.1
Year: 2024, type: Conference abstract
2023
-
Functional consequences of different distribution of NCX and PMCA between t-tubular and surface membranes in a model of the human ventricular cardiomyocyte
Year: 2023, type: Conference abstract
-
Funkční analýza varianty S1021Qfs*98 v kanálu KCNH2 (genu hERG)
Year: 2023, type: Conference abstract
-
Kardiomyocyty diferencované z lidských indukovaných pluripotentních buněk: Výhody a úskalí jejich využití při studiu dědičných arytmií
Year: 2023, type: Conference abstract