Project information
Involvement of Czech Translational Medicine Infrastructure to the European Advanced Translational Research Infrastructure in Medicine
(EATRIS-ERIC-CZ)
- Project Identification
- LM2018133
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Institute of Microbiology of the ASCR, v. v. i.
Institute of Experimental Medicine of the ASCR, v. v. i.
Institute of Nuclear Physics
Institute of Macromolecular Chemistry of the ASCR, v. v. i.
Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Charles University
Palacký University, Olomouc
- Responsible person doc. MUDr. Marián Hajdúch, Ph.D.
In 2011, the Czech Republic acceded to the European Advanced Translational Research Infrastructure in Medicine (EATRIS) consortium and this transitional phase lasted even in 2013. EATRIS entered in fall 2013 to ERIC (EATRIS-ERIC) and the Czech Republic became one of the founding countries. At the national level, the national node was built according to the schedule in 2010-2014 (Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc - IMTM), and in 2013/2014 we have created the national network, where the following institutions joined: Institute of Chemical Technology Prague (ICT), Institute of Organic Chemistry and Biochemistry AS CR, v.v.i. (IOCB), Charles University in Prague, First Faculty of Medicine (CU), Institute of Macromolecular Chemistry AS CR, v.v.i. (IMC), Masaryk University, Central-European Technology Institute (CEITEC), Nuclear Physics Institute of the ASCR, v.v.i. (NPI), Institute of Microbiology AS CR, v.v.i. (IM). Majority of these institutions have already signed an access agreement to EATRIS-ERIC (http://www.eatris.eu/about/simpleinstitutions.html). Czech institutions are actively involved in the activities of platforms Small Molecules, Biomarkers, Vaccines, and Imaging and Tracing. The mission of the current infrastructure project proposal EATRIS-ERIC-CZ is to further develop a dynamic and collaborative environment that will support chemical, biomedical, and clinical research, and speed up its transfer into clinical practice. It will connect and facilitate collaboration of top national research institutions and hospitals in the research partnership. EATRIS-ERIC-CZ will lead to the development of new knowledge and it will place the Czech Republic among nationally and internationally recognized centres of excellence in molecular and translational medicine directly linked to EATRIS-ERIC and other major biomedical infrastructures.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 21
2022
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New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity
Pharmaceutics, year: 2022, volume: 14, edition: 8, DOI
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Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects
GEROSCIENCE, year: 2022, volume: 44, edition: 1, DOI
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Non-psychotropic cannabinoids as inhibitors of TET1 protein
Bioorganic Chemistry, year: 2022, volume: 124, edition: July 2022, DOI
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Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration
Biomedicine & Pharmacotherapy, year: 2022, volume: 154, edition: October 2022, DOI
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Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient
CLINICAL CASE REPORTS, year: 2022, volume: 10, edition: 3, DOI
2021
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Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
GENOME BIOLOGY, year: 2021, volume: 22, edition: 1, DOI
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Distribution of SARS-CoV-2 Lineages in the Czech Republic, Analysis of Data from the First Year of the Pandemic
Microorganisms, year: 2021, volume: 9, edition: 8, DOI
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Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro
Journal for ImmunoTherapy of Cancer, year: 2021, volume: 9, edition: 8, DOI
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Novel Mitochondria-targeted Drugs for Cancer Therapy
Mini-reviews in medicinal chemistry, year: 2021, volume: 21, edition: 7, DOI
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T-Cell Activation: Post-Infection Diagnostic Tool for COVID-19
Folia biologica, year: 2021, volume: 67, edition: 1