Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
-
Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 327
2022
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Characterizing toxicity pathways of fluoxetine to predict adverse outcomes in adult fathead minnows (Pimephales promelas)
SCIENCE OF THE TOTAL ENVIRONMENT, year: 2022, volume: 817, edition: APR, DOI
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Infrared Laser Desorption of Intact Nanoparticles for Digital Tissue Imaging
Analytical Chemistry, year: 2022, volume: 94, edition: 51, DOI
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Instruct Council Meeting
Year: 2022, type: Popularization text
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Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
Frontiers in Cell and Developmental Biology, year: 2022, volume: 10, edition: February 2022, DOI
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Magainin 2 and PGLa in Bacterial Membrane Mimics III: Membrane Fusion and Disruption.
Biophysical Journal, year: 2022, volume: 121, edition: 5, DOI
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Measurement of Liver Stiffness using Atomic Force Microscopy Coupled with Polarization Microscopy
Journal of Visualized Experiments, year: 2022, volume: 2022, edition: 185, DOI
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Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel
Year: 2022, type: Conference abstract
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Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel
Folia Mendeliana : supplementum ad Acta Musei Moraviae, year: 2022, volume: 58, edition: 1
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Metal Oxide Laser Ionization Mass Spectrometry Imaging of Fatty Acids and Their Double Bond Positional Isomers
Analytical Chemistry, year: 2022, volume: 94, edition: 25, DOI
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Methods for Characterization of Biomolecular Interactions: Classical versus modern
Year: 2022, type: Workshop