Project information
Application of computer image analysis in optical microscopy
- Project Identification
- MSM 143300002
- Project Period
- 1/1999 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Informatics
- Keywords
- image analysis; image processing; segmentation; preprocessing; deconvolution; 3D analysis; 3D reconstruction; mathematical morphology; parallel computing; parallel algorithms; optical microscopy; confocal microscopy; automation; automated microscopy
Aim: The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis. The proposal assumes both continuation of running research of cell nucleus structure with clinical applications in diagnostics and prevention of leukemias and other cancer diseases as well as extension of the research into other application areas of computer analysis of microscopic images, biomedical as well as industrial. Content: Especially the algorithms of image preprocessing and segmentation will be studied with emphasis on deconvolution of 3D images, mathematical morphology operations and 3D image reconstruction from a series of 2D image slices. An intensive research will be led also in the area of parallel image analysis algorithms and parallelization of selected algorithms on multi-processor workstations using the equipment of Supercomputing centre MU.
Results
The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis.
Publications
Total number of publications: 88
2004
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Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells
Biophysics of the Genome, year: 2004
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Cytological study of DNA methylation and histone methylation patterns in human cell lines
Biophysics of the Genome, year: 2004
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Fast Marching 3D Reconstruction of Interphase Chromosomes
Computer Vision and Mathematical Methods in Medical and Biomedical Image Analysis, year: 2004
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Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches.
Biophysics of the Genome, year: 2004
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High-Resolution Cytometry Network Project: Client/Server System for 3D Optical Microscope Data Storage and Analysis
2nd International Symposium on 3D Data Processing, Visualization, and Transmission, year: 2004
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Image analysis of the movement of sub-cellular structures
Biophysics of the Genome, year: 2004
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In vivo imaging of cell interior using automated high-resolution cytometry
Biophysics of the Genome, year: 2004
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Rapid Image Acquisition of Living Cells and its Limits
Biophysics of the Genome, year: 2004
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Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo
Year: 2004, type: Conference abstract
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Towards a Fully Automated Tissue Cell Segmentation Method
Visualization, Imaging, and Image Processing, year: 2004