Fast Marching 3D Reconstruction of Interphase Chromosomes

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Authors	MATULA Pavel HUBENÝ Jan KOZUBEK Michal
Year of publication	2004
Type	Article in Proceedings
Conference	Computer Vision and Mathematical Methods in Medical and Biomedical Image Analysis
MU Faculty or unit	Faculty of Informatics
Citation
Field	Informatics
Keywords	fast marching method; deformable models; 3D object reconstruction; biomedical application; interphase chromosome
Description	Reliable 3D reconstruction of interphase chromosomes imaged using confocal microscopy is an important task in cell biology. Computer model of chromosome territories enables performing necessary measurements and consequently making morphological studies. A large number of processed objects is necessary to ensure statistical significance of the results. Therefore an automated procedure is needed. We have developed a successful algorithm for 3D reconstruction of chromosome territories on the basis of well-known fast marching algorithm. The fast marching algorithm solves front evolution problem similarly to deformable models but in an effective way with the time complexity O(n log n).
Related projects:	Threedimensional analysis of cell nuclei using image cytometry Application of computer image analysis in optical microscopy