Project information
Elucidating the role and molecular mechanism of Neuratin (NNAT) in neural induction (NEURALDEVESTEM)

Information

This project doesn't include Faculty of Sports Studies. It includes Faculty of Medicine. Official project website can be found on muni.cz.
Project Identification
2SGA2878
Project Period
4/2011 - 3/2013
Investor / Pogramme / Project type
South-Moravian Region
MU Faculty or unit
Faculty of Medicine

Our novel findings show Nnat initiates neural induction in mouse ES cells through
increasing intracellular Ca2+ ([Ca2+]i) by antagonising Ca2+ -ATPase (Sarco/ Endoplasmic
Reticulum Ca2+-ATPase, SERCA isoform 2, SERCA2) in the endoplasmic reticulum, which in turn
increases the phosphorylation of Erk1/2 and inhibits the BMP4 pathway, leading to neural induction
in conjunction with FGF/Erk pathway (Fig. 1) (2) (for more details, please see section 3.2). Based
on this we propose that NNAT plays a similar role in hES cells.

Publications

Total number of publications: 1


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