Project information
Application of biophysical methods in biotechnological and clinical praxis
- Project Identification
- IBS5004107
- Project Period
- 1/2001 - 12/2005
- Investor / Pogramme / Project type
-
Academy of Sciences of the Czech Republic
- Programme of Targeted Research and Development Support
- MU Faculty or unit
-
Faculty of Science
- Keywords
- DNA absorption; two-dimensional condensation; electrode double layer; electrochemical impedance; vol
- Cooperating Organization
-
Institute of Biophysics
- Responsible person prof. RNDr. Vladimír Vetterl, DrSc.
The cooperation between three laboratories of the Institute of Biophysics proceeding from the knowledge of the physical principles of interactions of nucleis acids and model compounds with metal surfaces and with ligands (tumor supresor p53, cytostatics) will be further developed. The cooperation will be aimed on the one hand to the development of a biosensor for detection of DNA damage and detection of the binding of ligand to DNA, on the other hand to the development of new cytostatics based on cis-Pt with a higher antitumor activity and lower mutagenic effect. New results can be expected especially due to the interconnection of the research at the physical, electrochemical and molecular biological levels, leading to publications in high quality international journals. The subject of the proposed project is up-to-date as it follows from the interests of manufacturers and their direct involvement in the project.
Publications
Total number of publications: 24
2002
-
Použití tenkých filmových elektrod v elektrochemické analýze nukleových kyselin a jejich složek
Moderní elektrochemické metody, XXII celostátní seminář, Sborník přednášek, year: 2002
-
Thin film mercury electrodes in electrochemical analysis of the nucleic acids and their componends
Book of Abstracts, p.83, year: 2002
2001
-
Studium interakcí nukleových kyselin s povrchy modifikovaných elektrod elektrochemickou impedanční spektroskopií.
Book of Abstracts. XXIV.dny lékařské biofyziky, year: 2001
-
Two-dimensional condensation of nucleic acid components at mercury film and gold electrodes
Book of Abstracts, XVI th International Symposium on Bioelectrochemistry and Bioenergetics, year: 2001