Project information
Gene Diagnostics and Therapy of Multiform Glioblastoma (COST)

Information

This project doesn't include Faculty of Sports Studies. It includes Faculty of Medicine. Official project website can be found on muni.cz.

Project Identification

OC B19.001

Project Period

1/2001 - 9/2006

Investor / Pogramme / Project type

Ministry of Education, Youth and Sports of the CR

COST

MU Faculty or unit

Faculty of Medicine

doc. MUDr. Pavel Cejpek, CSc.

Other MU Faculty/Unit

Faculty of Science

prof. RNDr. Jiřina Relichová, CSc.

Keywords

Gene Diagnostics, Therapy, Multiform Glioblastoma

The substance of the project consists in a precise selective removal of tumor tissue from different parts of the brain tumor by means of computer-navigated stereotaxis, and subsequent molecular-genetic processing of samples of tumor tissue. The aim is to obtain data on the types of genetic abnormalities from different parts of multiform glioblastoma, and to acquire new knowledge that could be used in its treatment. Another aim of the project is to develop and apply new methods and technologies (e.g. FISH # fluorescence in-situ hybridization, CGH # comparative genomic hybridization) employed in the detection of structural and numerical defects of chromosomes in the solution of problems of GBM. A special point of the study will be the correlation between deletions, hyperdiploid or amplification types and translocations of genetic material, and the prognostic significance of these specific findings in GBM.

Publications

Total number of publications: 18

2004

Molecular Cytogenetic Characterization of Glioblastoma Using the Technique of in situ Fluorescence Hybridization, Comparative Genome Hybridization and Spectral Karyotyping.

CEJPEK Pavel KUGLÍK Petr VESELSKÁ Renata PEŠÁKOVÁ Martina KRUPA Petr RELICHOVÁ Jiřina VYBÍHAL Václav MLEJNEK Petr LŽIČAŘOVÁ Eva HORKÝ J.

Article in Proceedings

9th European Workshop on Cytogenetics and Molecular Genetics of Human Solid Tumours - Book of abstracts, year: 2004
Nestin expression in cell lines derived from high-grade astrocytomas.

VESELSKÁ Renata KUGLÍK Petr CEJPEK Pavel HUBLAROVÁ Pavla ŠVÁCHOVÁ Hana RELICHOVÁ Jiřina

Article in Proceedings

International Journal of Mol. Medicine 14 (Sup. 1) - the 9th World Congress on Advances in Oncology and the 7th International Symposium on Molecular Medicine, year: 2004

2003

Genová diagnostika multiformního glioblastomu

CEJPEK Pavel KUGLÍK Petr KRUPA Petr VESELSKÁ Renata PEŠÁKOVÁ Martina RELICHOVÁ Jiřina VYBÍHAL Václav MLEJNEK Petr LŽIČAŘOVÁ Eva HORKÝ Jan

Conference abstract

Year: 2003, type: Conference abstract
Kultivace buněk solidních tumorů in vitro pro účely genetické diagnostiky

VESELSKÁ Renata KUGLÍK Petr HUBLAROVÁ Pavla ŠVÁCHOVÁ Hana RELICHOVÁ Jiřina CEJPEK Pavel

Conference abstract

Year: 2003, type: Conference abstract
Molecular cytogenetic characterisation of glioblastoma multiforme by fluorescence in situ hybridization (FISH)

KUGLÍK Petr PEŠÁKOVÁ Martina VESELSKÁ Renata OLTOVÁ Alexandra KUPSKÁ Renata RELICHOVÁ Jiřina CEJPEK Pavel

Conference abstract

Year: 2003, type: Conference abstract
Molecular cytogenetic and immunochemical study of high-grade astrocytomas

KUGLÍK Petr VESELSKÁ Renata HUBLAROVÁ Pavla ŠVÁCHOVÁ Hana PEŠÁKOVÁ Martina OLTOVÁ Alexandra RELICHOVÁ Jiřina CEJPEK Pavel

Conference abstract

Year: 2003, type: Conference abstract
Molekulárně cytogenetická charakterizace glioblastomu pomocí techniky fluorescenční hybridizace in situ, komperativní genomové hybridizace a spektrálního karyotypování.

KUGLÍK Petr PEŠÁKOVÁ Martina VESELSKÁ Renata OLTOVÁ Alexandra KUPSKÁ Renata RELICHOVÁ Jiřina CEJPEK Pavel

Conference abstract

Year: 2003, type: Conference abstract
Nestin expression in cell lines derived from high-grade astrocytomas.

VESELSKÁ Renata KUGLÍK Petr HUBLAROVÁ Pavla ŠVÁCHOVÁ Hana LŽIČAŘOVÁ Eva RELICHOVÁ Jiřina CEJPEK Pavel

Conference abstract

Year: 2003, type: Conference abstract