Mathematical model of peripheral blood stem cell harvest kinetics

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Authors

MAYER Jiří POSPÍŠIL Zdeněk KOŘÍSTEK Zdeněk

Year of publication 2003
Type Article in Periodical
Magazine / Source Bone Marrow Transplantation
MU Faculty or unit

Faculty of Science

Citation
Web http://www.nature.com/cgi-taf/DynaPage.taf?file=/bmt/journal/v32/n8/abs/1704226a.html
Field Oncology and hematology
Keywords mathematical model; cell separator; cell collection; peripheral blood stem cells; CD34+ cells; hematopoiesis
Description A mathematical model of peripheral blood stem cell harvest was developped, taking two new parameters - number of recruited cells and efficiency of collection - into consideration in addition to concentration and collected ammount of cells. This model was tested on 241 harvest procedures in cancer patients, donors of allogenetic PBSC, and platelet donors, using different collection procedures, with Cobe Spectra Cell separator.
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