Akutní lymfoblastická leukémie u kojenců

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Title in English	Acute Lymphoblastic Leukemia in Infants
Authors	STARÝ J. GAJDOŠ P. TRKA J. HAK J. MIHÁL V. BLAŽEK B. HRSTKOVÁ Hana HRUŠÁK O. MICHALOVÁ K. JAROŠOVÁ M. JABALI Y.
Year of publication	2002
Type	Article in Periodical
Magazine / Source	Transfúz. Hemat. dnes
MU Faculty or unit	Faculty of Informatics
Citation
Field	Paediatry
Keywords	acute lymphoblastic leukemia; infants; t(4:11); fusion gene MLL-AF4
Description	The therapeutic results in children with acute lymphoblastic leukaemia (ALL) are improving continuously with modern treatment protocols of combined chemotherapy. Approximately 75% children and adolescents can be cured from their leukaemia. Among infants younger than one year ALL is a rare disease. Typical infant ALL originates from very early precursors of B cells with a specific genotype, large leukaemic mass on diagnosis and high risk of early relapse. Between 1990-2000, 671 children and adelescents 0-18 years old