Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells

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Authors	LISKOVA Veronika CHOVANCOVA Barbora BABULA Petr REZUCHOVA Ingeborg PAVLOV Kristina Ploth MATUSKOVA Miroslava KRIŽANOVÁ Oľga
Year of publication	2023
Type	Article in Periodical
Magazine / Source	Frontiers in Oncology
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1178021/full
Doi	http://dx.doi.org/10.3389/fonc.2023.1178021
Keywords	cystathionine beta-synthase; cytoskeleton; beta-tubulin; colorectal carcinoma cells; xenografts
Description	Background: Cystathionine beta-synthase (CBS), one of three enzymes that endogenously produce hydrogen sulfide, is extensively studied for its relevance in the cells of various tumors. In our previous work, we observed that the immunofluorescence pattern of CBS is very similar to that of tubulin and actin. Therefore, we focused on the potential interaction of CBS with cytoskeletal proteins beta-actin and beta-tubulin and the functional relevance of the potential interaction of these proteins in colorectal carcinoma cell lines.