An Organotypic Assay to Study Epithelial-Fibroblast Interactions in Human Breast

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Authors

SUMBAL Jakub GUDJONSSON Thorarinn TRAUSTADOTTIR Gunnhildur Asta SUMBALOVÁ KOLEDOVÁ Zuzana

Year of publication 2022
Type Chapter of a book
MU Faculty or unit

Faculty of Medicine

Citation
Description Epithelial–stromal interactions play an essential role in regulation of mammary gland development, homeostasis, and tumorigenesis. Fibroblasts constitute a substantial proportion of mammary gland stromal cells in human breast and have been recognized for their paracrine signaling and extracellular matrix production and remodeling roles during normal breast development as well as in breast cancer. However, our current knowledge on human breast fibroblast functions is incomplete. Here we provide a detailed protocol for an organotypic human breast assay to facilitate research in the roles of human breast fibroblasts in mammary epithelial morphogenesis and early tumorigenesis.
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