LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.

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Authors

KRZYŽÁNKOVÁ Miroslava CHOVANOVÁ Silvia CHLAPEK Petr RÁDSETOULAL Matěj NERADIL Jakub ZITTERBART Karel ŠTĚRBA Jaroslav VESELSKÁ Renata

Year of publication 2014
Type Article in Periodical
Magazine / Source Tumor Biology
MU Faculty or unit

Faculty of Science

Citation
Web http://link.springer.com/article/10.1007%2Fs13277-014-2019-5
Doi http://dx.doi.org/10.1007/s13277-014-2019-5
Field Fertilization, soil processing
Keywords osteosarcoma; all-trans retinoic acid; caffeic acid; celecoxib; osteogenic differentiation
Description In this study, the effects of combined treatment with all-trans retinoic acid (ATRA) and lipoxygenase/cyclooxygenase inhibitors were examined in two osteosarcoma cell lines, Saos-2 and OSA-01. Caffeic acid and celecoxib were used as inhibitors of 5-lipoxygenase and of cyclooxygenase-2, respectively. Changes in the cell proliferation, matrix mineralization, and occurrence of differentiation markers were evaluated in treated cell populations at intervals. The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines. In contrast, celecoxib showed the same effect in Saos-2 cells only. Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid. The increased expression of osteogenic differentiation markers was observed in both cell lines after the combined application of ATRA and inhibitors.
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