MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway

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Authors	SLABÝ Ondřej
Year of publication	2013
Type	Article in Periodical
Magazine / Source	Medical Hypotheses
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.sciencedirect.com/science/article/pii/S0306987712005142#
Doi	http://dx.doi.org/10.1016/j.mehy.2012.11.033
Field	Oncology and hematology
Keywords	miR-190; microRNA; neuroblastoma; TrkB pathway
Description	Almost one third of all children with advanced stage neuroblastoma (NBL) is incurable. TrkB expressing NBLs frequently have MYCN amplification and are very aggressive and often fatal tumors. Little is known about the mechanisms by which TrkB is regulated. Here, we suggest new mechanism by which TrkB could be regulated. We hypothesize that miR-190 leads to aggressive phenotype of NBL through indirect activation of TrkB pathway, whereas NEUROD1 presents link between miR-190 and TrkB pathway.
Related projects:	CEITEC - Central European Institute of Technology