Visfatin and its role in obesity development

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Authors

ŠŤASTNÝ Jiří BIENERTOVÁ VAŠKŮ Julie VAŠKŮ Anna

Year of publication 2012
Type Article in Periodical
Magazine / Source Diabetes & Metabolic Syndrome: Clinical Research & Reviews
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.dsx.2012.08.011
Field Endocrinology, diabetology, metabolism, nutrition
Keywords Visfatin; NAMPT; Adipocytokines; Lipid metabolism; Obesity
Description Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamide phosphoribosyltransferase (NAMPT). In this review, we summarize the main documented effects of Visfatin on metabolism in humans, with special emphasis put on the pathways associated with obesity.

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