Informace o projektu
Mechanizmy opravy DNA u rostliny Arabidopsis thaliana
(DNAREP)
- Kód projektu
- MUNI/R/1364/2023
- Období řešení
- 3/2024 - 12/2025
- Investor / Programový rámec / typ projektu
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Masarykova univerzita
- Grantová agentura MU
- CAREER RESTART
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
In the proposed project we will address the question of how plants deal with DNA damage, particularly what types of primary DNA lesions are formed, at which genomic sites they accumulate and what kind of protein complexes are involved in the repair of damaged DNA template. We will focus on the implementation of sensitive microscopic, genomic and biochemical approaches that will allow us to effectively investigate the genome stability in wild plants and plants defective for genes encoding histone chaperones, proteins of repair pathways or e.g. replication complexes, and monitor DNA damage profile caused by genotoxic stress.
Publikace
Počet publikací: 3
2024
-
Histone Chaperone Deficiency in Arabidopsis Plants Triggers Adaptive Epigenetic Changes in Histone Variants and Modifications
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KU70 and CAF-1 in Arabidopsis: Divergent roles in rDNA stability and telomere homeostasis
Plant Journal, rok: 2024, ročník: 118, vydání: 6, DOI
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The histone chaperones ASF1 and HIRA are required for telomere length and 45S rDNA copy number homeostasis
Plant Journal, rok: 2024, ročník: 120, vydání: 3, DOI