Informace o projektu
Metabolic symbiosis between cancer cells and cancer-associated fibroblasts in head and neck cancer
- Kód projektu
- GA21-06873S
- Období řešení
- 1/2021 - 12/2023
- Investor / Programový rámec / typ projektu
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Grantová agentura ČR
- Standardní projekty
- Fakulta / Pracoviště MU
- Lékařská fakulta
- Spolupracující organizace
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Fakultní nemocnice v Motole
- Odpovědná osoba prof. MUDr. Jan Betka, DrSc., FCMA
Head and neck squamous cell carcinoma (HNSCC) represents the sixth leading cancer by incidence worldwide. The prognosis of HNSCC is based on the TNM staging system, which ultimately results in the same treatment for different HNSCC tumors. This heterogeneity may lie in distinct metabolic profiles of individual HNSCC tumors. Many types of cancer exhibit metabolic symbiosis between tumor cells and cells of the surrounding stroma, mainly cancer-associated fibroblasts (CAFs). This process involves transport of catabolites from CAFs to adjacent cancer cells by various transporters, such as monocarboxylic acid transporters (MCTs), which allows cancer cells to produce ATP, stimulate proliferation and reduce apoptosis. In this project, we want to further study the metabolic symbiosis between the cancer cells and surrounding stromal CAFs. Furthermore, we would like to investigate the metabolic profiles of distinct compartments within the HNSCC stroma with an effort to find potential prognostic markers and therapeutic targets of HNSCC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 9
2024
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Glutamine and serum starvation alters the ATP production, oxidative stress, and abundance of mitochondrial RNAs in extracellular vesicles produced by cancer cells
Scientific Reports, rok: 2024, ročník: 14, vydání: 1, DOI
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Protein cargo in extracellular vesicles as the key mediator in the progression of cancer
Cell Communication and Signaling, rok: 2024, ročník: 22, vydání: 1, DOI
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RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment
International journal of cancer, rok: 2024, ročník: 155, vydání: 7, DOI
2023
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Autophagy modulators influence the content of important signalling molecules in PS-positive extracellular vesicles
Cell Communication and Signaling, rok: 2023, ročník: 21, vydání: 1, DOI
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Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, rok: 2023, ročník: 1878, vydání: 5, DOI
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Engine shutdown: migrastatic strategies and prevention of metastases
Trends in Cancer, rok: 2023, ročník: 9, vydání: 4, DOI
2022
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Advances in Cancer Metabolism and Tumour Microenvironment
Rok: 2022, druh: Článek v odborném periodiku (nerecenzovaný)
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Metabolic tricks of cancer cells
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, rok: 2022, ročník: 1877, vydání: 3, DOI
2021
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Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers
Molecular Cancer, rok: 2021, ročník: 20, vydání: 1, DOI