Informace o projektu
Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
- Kód projektu
- VS96097
- Období řešení
- 7/1996 - 12/2000
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Posílení výzkumu na vysokých školách
- Fakulta / Pracoviště MU
- Lékařská fakulta
An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes.A "case-control" study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common "civilization" diseases,as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods.It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied.
Publikace
Počet publikací: 74
2000
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Relation between the insertion/deletion polymorphisms in the gene coding for receptor associated protein (RAP) and plasma apolipoprotein AI (apoAI) and high-density lipoprotein cholesterol (HDL) levels
Clinical Genetics, rok: 2000, ročník: 57, vydání: 4
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Relations between behavioral risk factors and genomic constitution in essential hypertension
Homeostasis, rok: 2000, ročník: 40, vydání: 3-4
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Single Effect of Apolipoprotein B, (a), E Polymorphisms and Interaction between Plasminogen Activator Inhibitor-1 and Apolipoprotein(a) Genotypes and the Risk of Coronary Artery Disease in Czech Male Caucasians
Molecular Genetics and Metabolism, rok: 2000, ročník: 69, vydání: Feb
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Ultrafast detection of microsatellite repeat polymorphism in endothelin 1 gene by electrophoresis in short capillaries
Electrophoresis, rok: 2000, ročník: 21, vydání: 21
1999
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(CA/CT) dinucleotid repeat polymorphism in ET-1 gene in essential hypertension
Physiol Research, Suppl 1, rok: 1999
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Angiotensin I-converting enzyme and tumor necrosis beta gene polymorphisms in coronary artery disease: an association study
Cor et Vasa, rok: 1999, ročník: 41, vydání: 5
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Association analysis of 24-h blood pressure records with I/D ACE gene polymorphism and AB0 blood group system
Physiological Research, rok: 1999, ročník: 48, vydání: 2
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Association of 3 gene polymorphisms with atopic diseases
J Allergy Clin Immunology, rok: 1999, ročník: 103, vydání: 4
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Association of G82S Polymorphism in the RAGE gene With Skin Complications in Type 2 Diabetes
Diabetes Care, rok: 1999, ročník: 1999, vydání: 22(10)
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DDMT and IIMT genotype combinations of angiotensin-converting enzyme and angiotensinogen genes are associated with type A behavior pattern score
Homeostasis, rok: 1999, ročník: 39, vydání: 3-4