Biocompatible Xanthine-Quadruplex Scaffold for Ion-Transporting DNA Channels
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | The Journal of Physical Chemistry Letters |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | DOI: 10.1021/jz300559w |
| Doi | http://dx.doi.org/10.1021/jz300559w |
| Obor | Fyzikální chemie a teoretická chemie |
| Klíčová slova | molecular dynamics; guanine; adaptive biasing force; ion transport; free-energy |
| Přiložené soubory | |
| Popis | Molecular dynamics simulations and adaptive biasing force analysis of the quadruplex DNA dynamics in an explicit solvent reveal fundamentally different mechanisms of Na+ transport in xanthine- and guanine-based DNA systems. The barrier to the transport of K+ through the xanthine-based quadruplex is significantly lower than those reported for the guanine-based analogs. |
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