Nestin expression in high-grade osteosarcomas and its clinical significance

• Autoři: ZAMBO Iva; HERMANOVÁ Markéta; ADÁMKOVÁ KRÁKOROVÁ Dagmar; MÚDRY Peter; ZITTERBART Karel; KÝR Michal; VESELÝ Karel; ŠTĚRBA Jaroslav; VESELSKÁ Renata
• Rok publikování: 2012
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Oncology Reports
• Fakulta / Pracoviště MU: Lékařská fakulta
• Doi: http://dx.doi.org/10.3892/or.2012.1687
• Obor: Onkologie a hematologie
• Klíčová slova: osteosarcoma; nestin; prognosis; immunohistochemistry; immunofluorescence

Přiložené soubory

• Oncol_Rep_Early_Online_or_2012_1687.pdf

• Popis: Using immunohistochemistry and immunofluorescence, we evaluated nestin expression in tumor tissue samples from 45 patients with high-grade osteosarcomas. High levels of nestin expression detected by immunofluorescence were associated with worse clinical outcomes. However, high levels of nestin expression detected by immunohistochemistry trended towards shorter OS and EFS but did not reach statistical significance. Nestin does not seem to represent a powerful prognostic marker for patients with high-grade osteosarcomas.

Související projekty

• Molekulární podstata buněčných a tkáňových regulací