Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

• Autoři: RÉDOVÁ Martina; POPRACH Alexandr; NEKVINDOVÁ Jana; ILIEV Robert; RADOVÁ Lenka; LAKOMÝ Radek; SVOBODA Marek; VYZULA Rostislav; SLABÝ Ondřej
• Rok publikování: 2012
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Journal of Translational Medicine
• Fakulta / Pracoviště MU: Středoevropský technologický institut
• www: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340316/?tool=pubmed
• Doi: http://dx.doi.org/10.1186/1479-5876-10-55
• Obor: Onkologie a hematologie
• Klíčová slova: Renal cell carcinoma; MicroRNA; Serum; Biomarker
• Popis: There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been recently described as powerful circulating biomarkers in a wide range of solid cancers. Our aim was to identify miRNA signature that can distinguish the blood serum of RCC patients and matched healthy controls and validate identified miRNAs as potential biomarkers for RCC.

Související projekty

• CEITEC - středoevropský technologický institut