Neural stem cell marker nestin as a specific marker for plasma cells of multiple myeloma patients.

Logo poskytovatele

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

ŠVÁCHOVÁ Hana LEGARTOVÁ Soňa KUBICZKOVÁ Lenka ŠEVČÍKOVÁ Sabina HÁJEK Roman

Rok publikování 2011
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis Nestin, a class VI intermediate filament protein, is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Unexpectedly, our previous results confirmed nestin levels in mature CD138+ plasma cells (PC) of multiple myeloma (MM) by flowcytometry; significant differences were found between nestin levels in MM and individuals without any hematological malignancy. The purpose of this study was to analyze nestin protein in CD138+PC and CD138-bone marrow mononuclear cells (BM MNC) of MM patients and myeloma cell lines. Our analysis clearly confirmed presence of nestin protein in CD138+PC but excluded nestin in CD138-BMMNC of MM patients. These results indicate that nestin may be a tumor specific marker for MM. Nestin-positive myeloma cell lines (U266, MOLP-8)are suggested as a model for study of nestin functions in PC of MM patients.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info