Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI)

• Autoři: JONES Sarah; FLORENCE Margaret; ELLIS Ian; KAŇKOVÁ Kateřina; SCHOR Seth; SCHOR Ana
• Rok publikování: 2007
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Experimental Cell Research
• Fakulta / Pracoviště MU: Lékařská fakulta
• Obor: Genetika a molekulární biologie
• Klíčová slova: MSF; NGAL; lipocalin; keratinocytes; fibroblasts; HaCat
• Popis: Data presented in this communication indicate that MSF is constitutively expressed by keratinocytes in culture, but is rendered functionally inactive by the co-secretion of an inhibitor (MSFI). This inhibitor was identified as NGAL. MSFI activity was found in NGAL obtained from four different sources: keratinocytes, neutrophils and recombinant protein isolated from both procaryotic and eucaryotic sources. This is a novel activity of NGAL which does not seem to be mediated by previously reported mechanisms, such as iron transport or direct protein-protein binding.

Související projekty

• Zlepšení hojení ran u pacientů s diabetem: preklinické ověření role proteinu MSF