A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	JURAJDA Michal MUŽÍK Jan IZAKOVIČOVÁ HOLLÁ Lydie VÁCHA Jiří
Rok publikování	2002
Druh	Článek v odborném periodiku
Časopis / Zdroj	Molecular and Cellular Probes
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Obor	Genetika a molekulární biologie
Klíčová slova	single nucleotide polymorphism; matrix metalloproteinase
Popis	Matrix metalloproteinase-1 (MMP-1) is a member of the matrix metalloproteinase enzyme family that degrades components of the extracellular matrix. Recent studies have demonstrated several polymorphic sites in the promoter of the MMP-1 gene. A newly identified single nucleotide polymorphism (SNP) at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was also studied.
Související projekty:	Molekulární patofyziologie multigenních chorob