Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

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Publikace nespadá pod Fakultu sportovních studií, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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BASHEER Neha BUEE Luc BRION Jean-Pierre SMOLEK Tomas MUHAMMADI Muhammad Khalid HRITZ Jozef HROMADKA Tomas DEWACHTER Ilse WEGMANN Susanne LANDRIEU Isabelle NOVAK Petr MUDHER Amritpal ZILKA Norbert

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj Acta Neuropathologica Communications
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01748-5
Doi http://dx.doi.org/10.1186/s40478-024-01748-5
Klíčová slova Tau protein; Propagation; Spreading; Aggregation; Neurofibrillary tangles; Animal models
Popis The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.
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