Prenylated phenols with potent anti-inflammatory effects
| Autoři | |
|---|---|
| Rok publikování | 2023 |
| Druh | Další prezentace na konferencích |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Natural substances often have a pleiotropic effect and can affect several cellular processes in parallel. They can have parallel anti-inflammatory and antibacterial effects, together with the current antiviral effect. Their mechanism of action is complex. However, the problem of natural substances is often their limited solubility and consequently also problematic bioavailability (1). Series of prenylated phenols were isolated from Paulowniaceae, Moraceae, and Euphorbiaceae plants (2-5). As part of the lecture, we will introduce the isolation and identification of prenylated phenols with potential antiviral and anti-inflammatory effects, we will describe their bioactivity, their formulations to increase solubility, and will describe the possibilities of their further development. We described the effects of phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases, and also some in vivo experiments confirming activity. At the end, an improvement of solubility by incorporating of tested substances into liposomes was presented. |
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