Echogenicity of Brain Structures in Huntington's Disease Patients Evaluated by Transcranial Sonography - Magnetic Resonance Fusion Imaging using Virtual Navigator and Digital Image Analysis

Logo poskytovatele

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

KOZEL Jiri SKOLOUDIK David RESSNER Pavel MIKULCOVA Patricie DUSEK Petr HANZLIKOVA Pavla DVORACKOVA Nina HERYAN Tomas BARTOVA Petra

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj ULTRASCHALL IN DER MEDIZIN
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2081-1635
Doi http://dx.doi.org/10.1055/a-2081-1635
Klíčová slova Head/Neck; Neurology; Physics and Technology
Popis Purpose Transcranial sonography (TCS) magnetic resonance (MR) fusion imaging and digital image analysis are useful tools for the evaluation of various brain pathologies. This study aimed to compare the echogenicity of predefined brain structures in Huntington's disease (HD) patients and healthy controls by TCS- MR fusion imaging using Virtual Navigator and digitized image analysis. Materials and Methods The echogenicity of the caudate nucleus ( CN), substantia nigra (SN), lentiform nucleus (LN), insula, and brainstem raphe (BR) evaluated by TCS-MR fusion imaging using digitized image analysis was compared between 21 HD patients and 23 healthy controls. The cutoff values of echogenicity indices for the CN, LN, insula, and BR with optimal sensitivity and specificity were calculated using receiver operating characteristic analysis. Results The mean echogenicity indices for the CN (67.0 +/- 22.6 vs. 37.9 +/- 7.6, p < 0.0001), LN (110.7 +/- 23.6 vs. 59.7 +/- 11.1, p < 0.0001), and insula ( 121.7 +/- 39.1 vs. 70.8 +/- 23.0, p < 0.0001) were significantly higher in HD patients than in healthy controls. In contrast, BR echogenicity (24.8 +/- 5.3 vs. 30.1 +/- 5.3, p < 0.001) was lower in HD patients than in healthy controls. The area under the curve was 90.9 %, 95.5 %, 84.1 %, and 81.8 % for the CN, LN, insula, and BR, respectively. The sensitivity and specificity were 86 % and 96 %, respectively, for the CN and 90 % and 100 %, respectively, for the LN. Conclusion Increased CN, LN, and insula echogenicity and decreased BR echogenicity are typical findings in HD patients. The high sensitivity and specificity of the CN and LN hyperechogenicity in TCS-MR fusion imaging make them promising diagnostic markers for HD.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info