Allantoin overaccumulation enhances production of metabolites under excess of metals but is not tightly regulated by nitric oxide

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Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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DRESLER Slawomir KOVACIK Jozef SOWA Ireneusz WOJCIAK Magdalena STRZEMSKI Maciej RYSIAK Anna BABULA Petr TODD Christopher D.

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Hazardous Materials
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0304389422009281?via%3Dihub
Doi http://dx.doi.org/10.1016/j.jhazmat.2022.129138
Klíčová slova Antioxidants; Flavonoids; Malic acid; Reactive oxygen species; Ureides
Popis The aln-3 mutant overaccumulating allantoin and respective wild type (WT) strain of Arabidopsis thaliana were exposed to cadmium (Cd) or mercury (Hg) with or without nitric oxide (NO) donor (sodium nitroprusside, SNP) to study crosstalk, metabolic and oxidative changes between these nitrogen sources (organic vs. inorganic). The aln-3 accumulated over 10-fold more allantoin than WT with the effect of Cd and Hg differing in leaf and root tissue: aln-3 contained more ascorbic acid and phytochelatins when treated with Cd or Hg and more Cd in both organs. SNP depleted leaf Cd and root Hg accumulation in aln3 but had a positive impact on the amount of metabolites typically in WT plants, indicating potentially negative relation between allantoin and NO. In agreement, aln-3 roots showed lower NO signals in control or metal treatments, but higher ROS signal, and SNP had more pronounced impact in WT roots. Flavonol glycosides were more abundant in aln-3 and were affected more by metals than by SNP. Malate was the most affected Krebs acid with strong reaction to SNP and Hg treatment. Data indicate that allantoin overaccumulation influences the accumulation of specific metabolites but nitric oxide has a greater impact on the metabolite profile in WT.

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