Involvement of calcium signaling in different types of cell death in cancer

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Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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BABULA Petr KRIŽANOVÁ Oľga

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Neoplasma
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7567&category_id=180&option=com_virtuemart&vmcchk=1&Itemid=1
Doi http://dx.doi.org/10.4149/neo_2022_220127N121
Klíčová slova calcium transport systems; cell death; cancer
Popis Programmed cell death is a basic feature of chemotherapeutic (and also radiotherapeutic) intervention. Induction of cell death in tumor cells aims to kill preferentially the tumor cells, with minimal impact on the normal cells. Although apoptosis is the most obvious type of cell death induced by chemotherapeutics, several other types can also be activated, especially in conditions, where cells are resistant to apoptosis induction. Calcium signaling was shown to play an indisputable role in the activation of different types of cell death. Local increase of the calcium in time and precise place of this increase is secured by calcium transport systems. In this review, we summarized the involvement of some calcium transport systems in apoptosis, autophagy, necroptosis, ferroptosis, and mitophagy during cancer development and treatment.
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