Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis

Logo poskytovatele

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

SKOPALOVÁ Kateřina RADASZKIEWICZ Katarzyna Anna KAŠPÁRKOVÁ Věra STEJSKAL Jaroslav BOBER Patrycja JUNKAR Ita MOZETIC Miran CAPÁKOVÁ Zdenka LEHOCKÝ Marián KAŠPAROVÁ Martina PACHERNÍK Jiří HUMPOLÍČEK Petr

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj International Journal of Molecular Sciences
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.3390/ijms22020501
Doi http://dx.doi.org/10.3390/ijms22020501
Klíčová slova conducting polymer; polypyrrole; biocompatibility; neurogenesis; stem cells
Popis The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info