Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-kappa B Activation, Showing Anti-Inflammatory Effect in Vitro

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Publikace nespadá pod Fakultu sportovních studií, ale pod Farmaceutickou fakultu. Oficiální stránka publikace je na webu muni.cz.
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ACIKARA O.B. HOSEK J. BABULA Petr CVACKA J. BUDESINSKY M. DRACINSKY M. ISCAN G.S. KADLECOVA D. BALLOVA L. ŠMEJKAL Karel

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Molecules
Fakulta / Pracoviště MU

Farmaceutická fakulta

Citace
Doi http://dx.doi.org/10.3390/molecules21010043
Klíčová slova anti-inflammatory activity; IL-1; NF-B; Scorzonera; phenolic; TNF-; triterpen
Popis Scorzonera species are used in different folk medicines to combat many diseases, including the illnesses connected with inflammation. Previous experiments showed anti-inflammatory activity of Scorzonera extracts in vivo. S. latifolia, S. cana var. jacquiniana, S. tomentosa, S. mollis ssp. szowitsii, S. eriophora, S. incisa, S. cinerea, and S. parviflora extracts were, therefore, evaluated for their inhibitory activities of TNF- and IL-1 production, and NF-B nuclear translocation in THP-1 macrophages. The HPLC analysis was carried out to elucidate and to compare the composition of these extracts. Major compounds of the tested extracts have been isolated using different chromatographic techniques and further tested for their inhibitory activities on TNF- and IL-1 production. Several extracts showed promising anti-inflammatory activity in these in vitro tests. Results of HPLC analysis revealed chlorogenic acid as a compound present in all tested extracts. Hyperoside, quercetin-3-O--d-glucoside and rutin were also present in varying amount in some Scorzonera species analyzed. Furthermore, eight phenolics which were identified as quercetin-3-O--d-glucoside (1), hyperoside (2), hydrangenol-8-O-glucoside (3), swertisin (4), 7-methylisoorientin (5), 4,5-O-dicaffeoyl-quinic acid (6), 3,5-di-O-caffeoyl-quinic acid (7), and chlorogenic acid (8) have been isolated as major phenolic compounds of the tested extracts and, together with eight terpenoids (9-16) previously obtained from different Scorzonera species, have been tested for the inhibition of TNF- production, unfortunately with no activity comparable with standard.

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