The human V delta 2(+) T-cell compartment comprises distinct innate-like V gamma 9(+) and adaptive V gamma 9(-) subsets

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

Autoři	DAVEY M.S. WILLCOX C.R. HUNTER S. KASATSKAYA S.A. REMMERSWAAL E.B.M. SALIM M. MOHAMMED F. BEMELMAN F.J. CHUDAKOV Dmitriy OO Y.H. WILLCOX B.E.
Rok publikování	2018
Druh	Článek v odborném periodiku
Časopis / Zdroj	Nature Communications
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
Doi	http://dx.doi.org/10.1038/s41467-018-04076-0
Klíčová slova	ANTIGEN RECEPTOR; FETAL-DEVELOPMENT; MOLECULAR-BASIS; B30.2 DOMAIN; MAIT CELLS; GAMMA; BLOOD; RESPONSES; CYTOMEGALOVIRUS; REPERTOIRE
Popis	V delta 2(+) T cells form the predominant human gamma delta T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the V delta 2(+) compartment comprises both innate-like and adaptive subsets. V gamma 9(+) V delta 2(+) T cells display semi-invariant TCR repertoires, featuring public V gamma 9 TCR sequences equivalent in cord and adult blood. By contrast, we also identify a separate, V gamma 9(-) V delta 2(+) T-cell subset that typically has a CD27(hi)CCR7(+)CD28(+)IL-7R alpha(+) naive-like phenotype and a diverse TCR repertoire, however in response to viral infection, undergoes clonal expansion and differentiation to a CD27(lo)CD45RA(+)CX(3)CR1(+) granzymeA/B+ effector phenotype. Consistent with a function in solid tissue immunosurveillance, we detect human intrahepatic V gamma 9(-) V delta 2(+) T cells featuring dominant clonal expansions and an effector phenotype. These findings redefine human delta d T-cell subsets by delineating the V delta 2(+) T-cell compartment into innate-like (V gamma 9(+)) and adaptive (V gamma 9(-)) subsets, which have distinct functions in microbial immunosurveillance.
Související projekty:	CEITEC 2020