Identification of candidate genes underlying soft tissue sarcoma progression using a progression series of murine fibrosarcoma cell lines

• Autoři: HATINA J.; KRIPNEROVA M.; PARMAR H.S.; HOUDEK Z.; DVORAK P.; HOUFKOVA K.; PESTA M.; KUNCOVA J.; ŠÁNA Jiří; SLABÝ Ondřej
• Rok publikování: 2018
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Středoevropský technologický institut
• Popis: ntroduction Soft tissue sarcomas are known for their great variability in clinical behaviour, ranging from almost indolent lesions to rapidly metastasing tumours. Genes responsible for sarcoma progression have been poorly characterised by now. Towards this end, we established a unique single-background progression series of murine sarcoma cell lines, consisting of the slowly proliferating nonmotile and noninvasive cell line JUN-2, rapidly proliferating, motile and invasive cell line JUN-3, and the cell line JUN-2fos-3 that exhibits a unique transformation pattern, with little deregulation of cell growth and proliferation, but pronounced motility and invasiveness.

Související projekty

• Identifikace nových prognostických markerů a terapeutických cílových molekul u sarkomu měkkých tkání