Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting

• Autoři: ŠTACKO Peter; MUCHOVA Lucie; VITEK Libor; KLÁN Petr
• Rok publikování: 2018
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Organic Letters
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: https://pubs.acs.org/doi/10.1021/acs.orglett.8b02043
• Doi: http://dx.doi.org/10.1021/acs.orglett.8b02043
• Klíčová slova: PHOTOREMOVABLE PROTECTING GROUPS; GASEOUS SIGNALING MOLECULE; PHOTODYNAMIC THERAPY; FLUORESCENT-PROBES; METHYLENE-BLUE; BODIPY DYES; GREEN-LIGHT; RELEASE; H2S; DERIVATIVES
• Popis: The synthesis and photochemical properties of H2S-releasing BODIPY thiocarbamate photocage scaffolds activatable by visible-to-NIR (up to 700 nm) light to release carbonyl sulfide (COS), which is transformed to H2S using either isolated or natural carbonic anhydrase, is reported. The excellent uncaging cross section and high H2S release yields in in vitro experiments, including live-cell imaging, suggest that these photocages can serve as a platform for the bio-orthogonal phototriggered release within the tissue-transparent window.

Související projekty

• Výzkumná infrastruktura RECETOX
• Visible light-activated photocaged molecules for biological applications
• RECETOX RI - OP VVV
• Fotoaktivace CO a H2S jako plynných signálních molekul pro biologické a medicinální aplikace