Variability of antibiotic resistance plasmids in human and veterinary coagulase-negative staphylococci and possibility of their horizontal transfer
| Autoři | |
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| Rok publikování | 2018 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Coagulase-negative staphylococci (CoNS) are opportunistic pathogens and an important cause of both human and animal diseases. Treatment of these diseases is complicated by their common antimicrobial resistance which is caused by overuse of antibiotics mainly in the veterinary environment. Livestock strains are therefore assumed to serve as a reservoir of resistance genes often located on mobile genetic elements such as plasmids. In this study, we have characterised resistance plasmids in 62 strains belonging to 10 CoNS species of human and veterinary origin. Altogether we analyzed 12 S. petrasii strains, 6 S. sciuri, 8 S. haemolyticus, 11 S. epidermidis, 5 S. warneri, 6 S. chromogenes, 6 S. xylosus, 5 S. equorum, 2 S. simulans and 1 S. caprae and compared their plasmid content and resistance determinants. In 48 analysed strains (77 %), 107 different plasmids ranging in size between 1.3 and 38.5 kb were detected and their number in each strain varied between 1 and 6. In total 7 different antimicrobial resistance genes carried by plasmids were detected by PCR. In addition, identical plasmids found in human and veterinary strains indicate the possibility of their natural horizontal transfer and emphasize importance of CoNS as a source of resistance determinants. |
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