Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	MINÁŘ Luboš FELSINGER Michal ČÍHALOVÁ Marta ZLÁMAL Filip BIENERTOVÁ VAŠKŮ Julie
Rok publikování	2018
Druh	Článek v odborném periodiku
Časopis / Zdroj	GINEKOLOGIA POLSKA
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.5603/GP.a2018.0073
Klíčová slova	squamous cell vulvar cancer; surgical treatment; tumour-free pathological margins; local recurrence
Popis	Objectives:To evaluate risk factors associated with the local recurrence of invasive squamous cell vulvar cancer in patient group with tumor-free pathological margins. Material and methods: This is a retrospective analysis of 47 patients who underwent surgical treatment at University Hospital Brno, the Czech Republic between 2007 and 2014. 24 patients were classified as IB stage and three as II stage. A further 20 patients representing stage III showed the metastatic involvement of regional lymph nodes. Seven prognostic factors were analyzed in relation to local tumour recurrence: tumour size, margin distance, depth of invasion, lymphovascular space involvement (LVSI), midline involvement, metastatic lymph nodes and FIGO stage. Results: All prognostic factors were found to be statistically significant with respect to the risk of local recurrence. The highest risk of local recurrence was observed for the depth of invasion > 5 mm (HR, 12.42 [95% CI; 3.44-44.841) and for the presence of LVSI (HR, 10.83 [95% CI; 3.87-30.28]).The study also established a clear difference in the risk of local recurrence between patient groups with resection margin < 8 vs. >= 8 mm (HR, 4.91 [95% CI; 1.73-13.93; p = 0.003]. Conclusions: Tumour-free pathological margin of >= 8 mm is a major prognostic factor of local recurrence which can be influenced by the surgeon. A perfect knowledge of the extent of the disease prior to surgery supports adequately radical surgical trends. The emphasis is given on adequate radicality as well as on the reduction of overtreatment without worsening prognosis by simultaneously preserving the quality of life.