The mystery of the cerebellum: clues from experimental and clinical observations

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Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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LAWRENSON Charlotte BAREŠ Martin KAMONDI Anita KOVÁCS Andrea LUMB Bridget APPS Richard FILIP Pavel MANTO Mario

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Cerebellum and Ataxias
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://link.springer.com/article/10.1186/s40673-018-0087-9?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot
Doi http://dx.doi.org/10.1186/s40673-018-0087-9
Klíčová slova Cerebellum; Anatomy; History; Fear; Cognition; Motor; Timing; Tremor
Popis The cerebellum has a striking homogeneous cytoarchitecture and participates in both motor and non-motor domains. Indeed, a wealth of evidence from neuroanatomical, electrophysiological, neuroimaging and clinical studies has substantially modified our traditional view on the cerebellum as a sole calibrator of sensorimotor functions. Despite the major advances of the last four decades of cerebellar research, outstanding questions remain regarding the mechanisms and functions of the cerebellar circuitry. We discuss major clues from both experimental and clinical studies, with a focus on rodent models in fear behaviour, on the role of the cerebellum in motor control, on cerebellar contributions to timing and our appraisal of the pathogenesis of cerebellar tremor. The cerebellum occupies a central position to optimize behaviour, motor control, timing procedures and to prevent body oscillations. More than ever, the cerebellum is now considered as a major actor on the scene of disorders affecting the CMS, extending from motor disorders to cognitive and affective disorders. However, the respective roles of the mossy fibres, the climbing fibres, cerebellar cortex and cerebellar nuclei remains unknown or partially known at best in most cases. Research is now moving towards a better definition of the roles of cerebellar modules and microzones. This will impact on the management of cerebellar disorders.

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