Adiponectin gene variability and plasma levels in non-obese Czech patients with asthma

Logo poskytovatele

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

BOŘILOVÁ LINHARTOVÁ Petra JÁNOŠ Július IZAKOVIČOVÁ HOLLÁ Lydie

Rok publikování 2018
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis Background and Aim: Adiponectin (ADIPOQ) gene variants and ADIPOQ circulating levels were previously associated with obesity and asthma risk. This pleiotropic cytokine, which modifies inflammation, is produced by the adipose tissue and T cells, as recently described. Obesity has a significant impact on asthma risk, phenotype, and prognosis. The aims of this study were to analyse ADIPOQ single nucleotide polymorphism (SNP) and ADIPOQ plasma levels in non-obese Czech patients with asthma and systematically healthy subjects, and thus to investigate the possible impact of ADIPOQ in the pathogenesis of asthma independently of obesity. Methods: In total, 576 non-obese individuals (with a body mass index less than 30) were included in this case-control study: 303 patients with asthma and 273 systematically healthy controls. Clinical examination was performed, IgE levels were determined and skin-prick tests to assess the reactivity for various allergens were evaluated. All subjects were genotyped for ADIPOQ (rs1501299) SNP by qPCR method with a TaqMan fluorescent assay. ADIPOQ plasma levels were determined by enzyme linked immunosorbent assay (ELISA) kit in subgroups of 46 patients with asthma and 25 healthy controls. Results: Significant differences in allele and genotype frequencies of ADIPOQ (rs1501299) SNP between patients with asthma and controls were detected (P<0.001); carriers of GG genotype vs. those with GT+TT genotypes had a higher risk of developing asthma (P<0.001, OR=1.88, 95%CI: 1.35- 2.63). Plasma levels of ADIPOQ were similar between patients with asthma and controls; and they were independent of ADIPOQ (rs1501299) individual´s genotype. Conclusions: This is the first study focusing on ADIPOQ gene variability and asthma in Caucasian population. We suggest that ADIPOQ (rs1501299) SNP may be a marker of asthma risk for non-obese individuals.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info