Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups

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Publikace nespadá pod Fakultu sportovních studií, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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MICHLOVSKA L. VOJTOVA L. HUMPA Otakar KUCERIK J. ZIDEK J. JANCAR J.

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj RSC Advances
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA26222D#!divAbstract
Doi http://dx.doi.org/10.1039/c5ra26222d
Obor Fyzikální chemie a teoretická chemie
Klíčová slova ITACONIC ANHYDRIDE; COPOLYMERS; METHACRYLATE; COMPOSITES; OLIGOMERS; POLYMERS; DELIVERY; LACTIDE
Popis Biodegradable amphiphilic PLGA-PEG-PLGA triblock copolymers end-terminated with itaconic acid (ITA) having reactive double bonds were synthesized by ring opening polymerization. The prepared alpha,omega-itaconyl-PLGA- PEG-PLGA telechelic macromonomers were additionally covalently crosslinked under an inert atmosphere by blue light irradiation without the use of a further cross-linker resulting in end-linked polymeric networks. The effects of the ITA amount attached to the alpha,omega-itaconyl-PLGA-PEG-PLGA copolymers and the crosslinking time on swelling behaviours and hydrolytic stability of the prepared well-defined polymeric network were investigated. Physicochemical properties were characterized by proton and carbon nuclear magnetic resonance spectroscopy (H-1 NMR, C-13 NMR), proton nuclear magnetic resonance relaxometry, attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR) and thermogravimetric analysis (TGA). It was found that the hydrolytic stability of ITA modified PLGA-PEG-PLGA end-linked hydrogels enhances with both increasing the time of crosslinking and the amount of double bonds attached to alpha,omega-itaconyl-PLGA-PEG-PLGA polymer chains. In comparison with the original un-crosslinked alpha,omega-itaconyl-PLGA-PEG-PLGA copolymer, the hydrolytic stability of the end-linked hydrogels significantly increased. Three kinds of water fractions (unbound, weakly and strongly bonded) were determined by proton NMR relaxometry in hydrogels containing 63 mol% of ITA crosslinked for 40 minutes. Even for hydrogels surviving 32 days in water the NMR relaxometry showed structural collapse of the hydrogel probably due to breaking of end-linked nodes followed by hydrolysis faster than water diffusion after day 15 of immersion. End-linked alpha,omega-itaconyl-PLGA- PEG-PLGA hydrogels can be used in medical, biological or tissue engineering applications.
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